Themes &
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3 thematics:
6 scientific operating teams 2 support teams (management & animal facility) |
3 Themes
Evolution, plasticity and emergence of pathogens
Biodiversity, genetic structures, genetic diversity and phenotypic characteristics.
Molecular factors involved in pathogenicity and their mechanisms of action. |
Infectious processes and the host-response
Localization and dissemination within the host.
Genetic mechanisms modulating pathogenesis. Mechanisms underlying the innate and adaptive immune response (especially at the genetic level). |
Contribution to a better control of diseasesAssessment and reliability of diagnostic
Knowledge on epidemiological cycles Breaking routes of transmission Improving host resistance Developing alternatives to drug treatment |
6 Research Teams
01-Prions
Pathogenesis of Prion- & Prion-like diseases Team's leader: Dr. Olivier Andreoletti Key words: Prions, Prions-like, transmission, zoonotic diseases, evolution Further readings: Animal prion diseases: the risks to human health. Brain Pathol. Houston F, Andréoletti O. 2019; Cellular mechanisms responsible for cell-to-cell spreading of prions. Vilette D, Courte J, Peyrin JM, Coudert L, Schaeffer L, Andréoletti O, Leblanc P. Cell Mol Life Sci. 2018 |
02- Viruses
Host-Virus Interactions and Vaccinology Team's team leader: Prof. Jean-Luc Guérin Key words: Influenza Viruses (D, A), respiratory viruses of poultry and ruminants, vaccines, high-throughput sequencing & emerging viruses Further readings: Pathogenesis, host innate immune response and aerosol transmission of Influenza D virus in cattle. Salem E, Hägglund S, Cassard H, Corre T, Näslund K, Foret C, Gauthier D, Pinard A, Delverdier M, Zohari S, Valarcher JF, Ducatez M, Meyer G.J Virol. 2019; Role of Backyard Flocks in Transmission Dynamics of Highly Pathogenic Avian Influenza A(H5N8) Clade 2.3.4.4, France, 2016-2017. Souvestre M, Guinat C, Niqueux E, Robertet L, Croville G, Paul M, Schmitz A, Bronner A, Eterradossi N, Guérin JL. Emerg Infect Dis. 2019 |
03- Mycoplasmas
Pathogenesis of ruminant mycoplasmoses Team's leader: Dr. Christine Citti Key words: Ruminant mycoplasmas, emergence, genomics & evolution, co-infection, vaccines Further readings: Horizontal Gene Transfers in Mycoplasmas (Mollicutes). Citti C et al. Curr Issues Mol Biol. 2018; Mycoplasmas under experimental antimicrobial selection: The unpredicted contribution of horizontal chromosomal transfer. Faucher M, Nouvel LX, Dordet-Frisoni E, Sagné E, Baranowski E, Hygonenq MC, Marenda MS, Tardy F, C. Citti. PLoS Genet. 2019 |
04- Host-response
Immunity and Alternatives to antibiotics Team's leader: Prof. Gilles Foucras Key words: Immunity, Inflammation, Ruminants, Genomics, Mammary Gland Further readings Molecular Analysis of A Short-Term Model Of β-Glucans-Trained Immunity Highlights The Accessory Contribution Of GM-CSF In Priming Mouse Macrophages Response. Walachowski S, Tabouret G, Fabre M, and Foucras G. Front Immunol 2017. A point Mutation in Suppressor Of Cytokine Signalling 2 (Socs2) increases the Susceptibility to Inflammation of the Mammary Gland while associated with higher Body Weight and Size and higher Milk Production in a Sheep Model. Rupp R, Senin P, Sarry J, Allain C, Tasca C, Ligat L, Portes D, Woloszyn F, Bouchez O, Tabouret G, Lebastard M, Caubet C, Foucras G*, Tosser-Klopp G*. PLoS Genet 2015 |
05- Parasites
Besnoitoises Team's leader: Prof. Philippe Jacquiet Key words: Besnoitia besnoiti, Apicomplexa, emergent vectorborne disease, Stomoxys calcitrans, control Frurther reading: Stomoxys calcitrans, mechanical vector of virulent Besnoitia besnoiti from chronically infected cattle to susceptible rabbit. Sharif S, Jacquiet P, Prevot F, Grisez C, Raymond-Letron I, Semin MO, Geffré A, Trumel C, Franc M, Bouhsira É, Liénard E. Med Vet Entomol. 2019; Phenotypic susceptibility to pyrethroids and organophosphate of wild Stomoxys calcitrans (Diptera: Muscidae) populations in southwestern France. Tainchum K, Shukri S, Duvallet G, Etienne L, Jacquiet P. Parasitol Res. 2018. Host-Nematode Interactions Team's leader: Dr. Hervé Hoste Key words: Gastro intestinal Nematodes, Anthelmintics; Bioactive plant, Nutraceuticals, Tannins, Goats, Sheep Further readings: Anthelmintic Activities against Haemonchus contortus or Trichostrongylus colubriformis from Small Ruminants Are Influenced by Structural Features of Condensed Tannins. Quijada J, Fryganas C, Ropiak HM, Ramsay A, Mueller-Harvey I, Hoste H. J Agric Food Chem. 2015; Interactions Between Nutrition and Infections With Haemonchus contortus and Related Gastrointestinal Nematodes in Small Ruminants. Hoste H, Torres-Acosta JF, Quijada J, Chan-Perez I, Dakheel MM, Kommuru DS, Mueller-Harvey I, Terrill TH.Adv Parasitol. 2016. |
06- Epidemiology in Animal Health
EPIDSA Team's leader: Ass. Prof. Timothée Vergne Key words: Disease management, surveillance and control; Epidemic dynamics; Antimicrobials; Livestock; Farmer behavior Furher readings Spatio-temporal patterns of highly pathogenic avian influenza virus subtype H5N8 spread, France, 2016 to 2017. Guinat, C., Nicolas, G., Vergne, T., Bronner, A., Durand, B., Courcoul, A., Gilbert, M., Guérin, J.-L., Paul, M.C., 2018. Euro Surveill 2018 Undetected Circulation of African Swine Fever in Wild Boar, Asia. Vergne T, Guinat C, Pfeiffer DU. Emerg Infect Dis. 2020 More here https://epidec.weebly.com/publications.html |